abstract：:Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature...

journal_title：Planta medica

authors： Wansi JD,Happi EN,Bavoua JL,Devkota KP,Sewald N

更新日期：2012-01-01 00:00:00

abstract：:Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1- 3) and six known compounds (4- 9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growt...

journal_title：Planta medica

authors： Luo Y,Wang H,Zhao YX,Zeng YB,Shen HY,Dai HF,Mei WL

更新日期：2011-12-01 00:00:00

abstract：:Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...

journal_title：Planta medica

authors： Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SS

更新日期：2011-12-01 00:00:00

abstract：:One new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A-D (2- 5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectra. C...

journal_title：Planta medica

authors： Zuo WJ,Dai HF,Chen J,Chen HQ,Zhao YX,Mei WL,Li X,Wang JH

更新日期：2011-11-01 00:00:00

abstract：:The present study assessed the absolute and relative bioavailabilities of dodeca-2 E,4 E,8 Z,10 E/ Z-tetraenoic acid isobutylamides (tetraenes), the main bioactive constituents in Echinacea, administered as pure compounds or in the form of an Echinacea purpurea root extract preparation. Tetraenes were administered ora...

journal_title：Planta medica

authors： Ardjomand-Woelkart K,Kollroser M,Magnes C,Sinner F,Frye RF,Derendorf H,Bauer R,Butterweck V

更新日期：2011-11-01 00:00:00

abstract：:EGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expre...

journal_title：Planta medica

authors： Zhang Y,Zheng L,Zhang J,Dai B,Wang N,Chen Y,He L

更新日期：2011-11-01 00:00:00

abstract：:Seven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6),...

journal_title：Planta medica

authors： He WJ,Chu HB,Zhang YM,Han HJ,Yan H,Zeng GZ,Fu ZH,Olubanke O,Tan NH

更新日期：2011-11-01 00:00:00

abstract：:One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the...

journal_title：Planta medica

authors： Sultana R,Hossain R,Adhikari A,Ali Z,Yousuf S,Choudhary MI,Ali MY,Zaman MS

更新日期：2011-11-01 00:00:00

abstract：:Valepotriates are iridoids found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species. On the other hand, unspecific cytotoxicity has also been described. Presently, however, no particular molecular target has been defined for these...

journal_title：Planta medica

authors： Bettero GM,Salles L,Rosário Figueira RM,Poser Gv,Rates SM,Noël F,Quintas LE

更新日期：2011-10-01 00:00:00

abstract：:Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

journal_title：Planta medica

authors： Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

更新日期：2011-10-01 00:00:00

abstract：:Olive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from OLEA EUROPAEA L. (Oleaceae family...

journal_title：Planta medica

authors： Zrelli H,Matsuka M,Araki M,Zarrouk M,Miyazaki H

更新日期：2011-10-01 00:00:00

abstract：:Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, is one of the most commonly used medicinal plants by Inuit and other First Nations peoples of Canada. The phenolic profile and seasonal variation of this commonly used medicinal plant remains largely unknown. To assess optimal harvesting time, R. tomento...

journal_title：Planta medica

authors： Black P,Saleem A,Dunford A,Guerrero-Analco J,Walshe-Roussel B,Haddad P,Cuerrier A,Arnason JT

更新日期：2011-09-01 00:00:00

abstract：:Both borneol and menthol are bioactive substances derived from Chinese herbal medicines. In order to understand the pharmacokinetics of borneol and menthol in Qingyan drop pills, a rapid, sensitive, and simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the simultaneous dete...

journal_title：Planta medica

authors： Xu X,Li Y,Hou J,Zhang S,Xu Y,Wang Y,Zhang Y,Liu C,He X

更新日期：2011-09-01 00:00:00

abstract：:In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic metho...

journal_title：Planta medica

authors： Slusarczyk S,Zimmermann S,Kaiser M,Matkowski A,Hamburger M,Adams M

更新日期：2011-09-01 00:00:00

abstract：:The species Ageratina pichinchensis (Asteraceae) has been used for a long time in Mexican traditional medicine for the treatment of different skin conditions and injuries. In this study, the healing capacity of the plant extracts obtained was evaluated and, in order to understand the mechanism of healing, we also anal...

journal_title：Planta medica

authors： Romero-Cerecero O,Zamilpa-Álvarez A,Ramos-Mora A,Alonso-Cortés D,Jiménez-Ferrer JE,Huerta-Reyes ME,Tortoriello J

更新日期：2011-07-01 00:00:00

abstract：:Owing to their high content of flavonoids and saponins, plantlets of Avena sativa L. (Poaceae) are likely to possess anti-inflammatory and immunoregulatory properties of value in the treatment of atopic dermatitis (AD). With a view to its potential use in atopic subjects at risk of developing sensitisation to dietary ...

journal_title：Planta medica

authors： Mandeau A,Aries MF,Boé JF,Brenk M,Crebassa-Trigueros V,Vaissière C,Teysseyre V,Bieber T

更新日期：2011-06-01 00:00:00

abstract：:Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic acti...

journal_title：Planta medica

authors： Liu H,Chou GX,Wang JM,Ji LL,Wang ZT

更新日期：2011-05-01 00:00:00

abstract：:Ocimum basilicum L. is an aromatic herb used in Brazil to treat illnesses such as respiratory and rheumatic problems, vomiting, and pain. In the present study, the chemical composition, acute toxicity, and antinociceptive effects of the essential oil (EO) of the cultivar "Maria Bonita" obtained from O. basilicum L. PI...

journal_title：Planta medica

authors： Venâncio AM,Onofre AS,Lira AF,Alves PB,Blank AF,Antoniolli AR,Marchioro M,Estevam Cdos S,de Araujo BS

更新日期：2011-05-01 00:00:00

abstract：:Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...

journal_title：Planta medica

authors： Chow NK,Fretz M,Hamburger M,Butterweck V

更新日期：2011-05-01 00:00:00

abstract：:Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8- EPI-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect...

journal_title：Planta medica

authors： López MR,de León L,Moujir L

更新日期：2011-05-01 00:00:00

abstract：:In this study, the significant hepatoprotective effect of dioscin against CCl₄-induced acute liver damage in mice was first discovered, and the effect produced by dioscin at the dose of 100 mg/kg was equal to the action produced by silymarin at the dose of 200 mg/kg. Then, 1-dimension gel electrophoresis was used to s...

journal_title：Planta medica

authors： Lu B,Yin L,Xu L,Peng J

更新日期：2011-03-01 00:00:00

abstract：:Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

journal_title：Planta medica

authors： Chen J,Chen JJ,Yang LQ,Hua L,Gao K

更新日期：2011-03-01 00:00:00

abstract：:This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centauri...

journal_title：Planta medica

authors： Pereira EM,Gomes RT,Freire NR,Aguiar EG,Brandão Md,Santos VR

更新日期：2011-03-01 00:00:00

abstract：:Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-...

journal_title：Planta medica

authors： Cha MR,Choi YH,Choi CW,Yoo DS,Kim YS,Choi SU,Kim YH,Ryu SY

更新日期：2011-03-01 00:00:00

abstract：:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by ana...

journal_title：Planta medica

authors： Chang CP,Chang HS,Peng CF,Lee SJ,Chen IS

更新日期：2011-01-01 00:00:00

abstract：:Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such a...

journal_title：Planta medica

authors： Sarris J,Teschke R,Stough C,Scholey A,Schweitzer I

更新日期：2011-01-01 00:00:00

abstract：:A new BIS-1-oxaquinolizidine alkaloid, 9'- EPI-3 β,3' β-dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua. ...

journal_title：Planta medica

authors： Li Y,Qin S,Guo YW,Gu YC,van Soest RW

更新日期：2011-01-01 00:00:00

abstract：:The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...

journal_title：Planta medica

authors： Sun S,Wang X,Wang C,Nawaz A,Wei W,Li J,Wang L,Yu DH

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of 7-epiclusianone (7-epi) on specific virulence attributes of Streptococcus mutans in vitro and on development of dental caries in vivo. 7-Epi was obtained and purified from fruits of Rheedia brasiliensis. We investigated its influence on surface-adsorbed glucosyltran...

journal_title：Planta medica

authors： Branco-de-Almeida LS,Murata RM,Franco EM,dos Santos MH,de Alencar SM,Koo H,Rosalen PL

更新日期：2011-01-01 00:00:00

abstract：:DNA technology provides a powerful tool to complement chemical analyses for authentication of Chinese medicinal plants and to ensure that herbal materials are not contaminated with ineffective or potentially harmful substitutes or adulterants. In the last two decades molecular biotechnology has provided sophisticated ...

journal_title：Planta medica

authors： Heubl G

更新日期：2010-12-01 00:00:00

abstract：:The flower buds of Lonicera japonica are widely used in Chinese medicine for their anti-inflammatory properties. The reason why L. japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA). In the present study, we isolated a hydroxycinnamoyl-CoA quina...

journal_title：Planta medica

authors： Peng X,Li W,Wang W,Bai G

更新日期：2010-11-01 00:00:00

abstract：:P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a...

journal_title：Planta medica

authors： Madgula VL,Ashfaq MK,Wang YH,Avula B,Khan IA,Walker LA,Khan SI

更新日期：2010-10-01 00:00:00

abstract：:The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...

journal_title：Planta medica

authors： Ge GB,Liang SC,Hu Y,Liu XB,Mao YX,Zhang YY,Luan HW,Qiu MH,Yang L

更新日期：2010-10-01 00:00:00

abstract：:The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also s...

journal_title：Planta medica

authors： Kour K,Sharma N,Chandan BK,Koul S,Sangwan PL,Bani S

更新日期：2010-10-01 00:00:00

abstract：:Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its eff...

journal_title：Planta medica

authors： Park KS

更新日期：2010-10-01 00:00:00

abstract：:An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...

journal_title：Planta medica

authors： Lata H,Chandra S,Khan IA,Elsohly MA

更新日期：2010-10-01 00:00:00

abstract：:Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

journal_title：Planta medica

authors： Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

更新日期：2010-10-01 00:00:00

abstract：:Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple mechanisms to resist the induction of programmed ce...

journal_title：Planta medica

authors： Fulda S

更新日期：2010-08-01 00:00:00

abstract：:Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...

journal_title：Planta medica

authors： Balunas MJ,Kinghorn AD

更新日期：2010-08-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...

journal_title：Planta medica

authors： Pinto-Garcia L,Efferth T,Torres A,Hoheisel JD,Youns M

更新日期：2010-08-01 00:00:00